The following information is required for the grant application:
1. Project title: Provide a concise and descriptive title for the proposed research project.
2. Project duration: Specify the proposed duration of the project, which should be 5 years.
3. Renewal possibility: Indicate whether the project is eligible for one competing renewal.
4. Research team: Provide details of the integrated, interdisciplinary research team, including their expertise in neurobiology, statistics, physics, mathematics, engineering, computer science, and data science.
5. Project description: Provide a comprehensive description of the proposed research project, focusing on examining dynamic circuit functions related to behavior using invasive neural recording and stimulating technologies in the human brain.
6. Research objectives: Clearly outline the overarching principles of circuit function to be investigated, within the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis.
7. Experimental design: Describe the experimental design and approach to manipulating relevant dynamic patterns of neural activity, controlling stimuli and/or behavior, and measuring resulting behaviors and/or perceptions.
8. Theoretical constructs: Explain how the proposed research will be guided by specified theoretical constructs, and how quantitative, mechanistic, and predictive models will be employed where appropriate.
9. Model systems: Justify the use of model systems, including the possibility of multiple species ranging from invertebrates to humans.
10. Data management: Outline how the project will manage its data and analysis methods within the framework developed and used by the proposed U19 project, and how it will exchange data with other BRAIN U19 awardees for further refinement and development.
11. Budget: Provide a detailed budget for the proposed research project, including funding requirements for personnel, equipment, supplies, and other necessary resources.
12. Impact and significance: Discuss the potential impact and significance of the proposed research on advancing the understanding of circuit function in the human brain and its implications for brain-related disorders and therapies.
13. References: Include a list of references cited in the project description and provide appropriate citations throughout the application.
14. Compliance: Ensure that the proposed research complies with all relevant ethical guidelines and regulations concerning human subjects research and invasive neural recording and stimulating technologies.
15. Collaboration plan: Describe how the multi-component team of research expertise will collaborate to cross boundaries of interdisciplinary collaboration and achieve the research objectives.
16. Biosketches: Include biosketches of all key personnel involved in the proposed research project
