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Catalyze: Enabling Technologies and Transformative Platforms for HLBS Research (R33 - Clinical Trials Not Allowed)

Grant Title: Catalyze: Enabling Technologies and Transformative Platforms for HLBS Research

Grant Description: This funding opportunity supports the further development of enabling technologies and transformative platforms to catalyze next-generation predictive, diagnostic, and therapeutic products for heart, lung, blood, and sleep (HLBS)-related disorders and diseases. The focus is on projects that have already overcome major feasibility gaps and demonstrated preliminary data but require additional development and validation. The goal is to encourage downstream demonstration, utilization, and adoption of these technologies. Applications should accelerate or transform the areas of early detection and screening, model development, clinical diagnosis, treatment, control, prevention, or epidemiology related to HLBS diseases and disorders. Applications proposing the application of existing technologies, where novelty lies in the biological or clinical target/question, are not eligible. This FOA is part of the NHLBI Catalyze program, which aims to advance projects to meet the entry criteria for the NHLBI Catalyze Product Definition or Preclinical FOAs.

Required Information for Application:

1. Project Title

2. Project Summary/Abstract

3. Scientific/Technical Abstract

4. Project Narrative

5. Specific Aims

6. Research Strategy/Plan

7. Preliminary Studies/Results

8. Significance/Impact

9. Innovation

10. Approach/Methodology

11. Timeline/Schedule

12. Budget

13. Justification for Budget

14. Facilities/Resources

15. Personnel/Team Members

16. Biosketches/CVs

17. Letters of Support/Collaboration

18. Regulatory Approvals (if applicable)

19. Data Sharing Plan

20. Intellectual Property Statement

21. Other Support/Funding

22. Compliance with NIH Policies

23. Human Subjects Research (if applicable)

24. Animal Use and Care (if applicable)

25. Responsible Conduct of Research

26. Letters of Reference (if required)

27. Conflict of Interest Disclosure

28. Previous Funding/Progress Report (if applicable)

29. Appendix (if applicable)

30. Other Attachments/Supplementary Material

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