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Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

List of required information for application:

1. Investigator's interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets.

2. Starting compounds (validated hits) for chemical optimization.

3. Bioassays for testing new analog compounds.

4. Description of the proposed research plan for the discovery and development of novel, small molecules.

5. Explanation of how the proposed research is relevant to the missions of NIMH, NEI, NIAAA, NIDA, NIA, and/or NIDCD.

6. Description of the potential use of the novel, small molecules in understanding biological processes.

7. Description of how the proposed research will contribute to the discovery and/or validation of novel, biological targets related to brain disease mechanisms.

8. Explanation of how the research will provide new insight into important disease-related biological targets and biological processes.

9. Summary of the main emphasis of the project, which should be on the discovery of in vivo chemical probes.

10. If interested in developing cell-based chemical probes, applicants may consider applying using the companion R21 mechanism TEMP-8443.

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Funding Amount

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Eligible Applicants

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Deadline to Apply

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88%

Approval rating across all Canadian funding programs

93%

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