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Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)

1. Research proposal on interventions to improve health in Native American populations

2. Description of the significant gap in knowledge that the research aims to address

3. Explanation of how the research will directly inform intervention development or adaptations

4. Description of the health promotion and disease prevention interventions to be developed, adapted, or tested

5. Explanation of how the research will test the efficacy or effectiveness of the interventions

6. Description of culturally informed treatment or recovery interventions to be tested

7. Explanation of how the research will test the efficacy or effectiveness of culturally informed interventions

8. Description of existing knowledge on intervention efficacy and the need for research on dissemination and implementation

9. Explanation of the barriers to adoption, integration, scale-up, and sustainability of effective interventions

10. Description of strategies to be developed and tested for overcoming these barriers

11. Explanation of the specific acute and chronic disease inequities experienced by Native American populations

12. Description of the unique sociopolitical, historical, and environmental stressors and risks faced by Native American populations

13. Explanation of how these stressors and risks may impact health conditions and the effectiveness of existing solutions

14. Description of the unique strengths and resiliencies of Native American populations that can mitigate stressors or inform intervention strategies

15. Explanation of how the research will build upon community knowledge, resources, and resilience

16. Description of science-based, culturally appropriate solutions to reduce morbidity and mortality

17. Explanation of how the research will identify and remediate precursors to diseases and disorders

18. Description of how the interventions will be designed for sustainability within the communities where they are tested

19. Explanation of the flexibility of the interventions to be readily adapted, disseminated, and scaled up to other communities

20. Description of the Native American populations included in the scope of the research (Alaska Natives, American Indians)

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88%

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93%

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