Grant Name: NEI Regenerative Medicine Clinical Trial Planning Grant (R34 - Clinical Trials Not Allowed)
Grant Description: The National Eye Institute (NEI) Audacious Goal Initiative (AGI) aims to advance vision science by regenerating cells in the retina to restore vision. The AGI focuses on photoreceptors and retinal ganglion cells in the eye. Photoreceptors, known as rods and cones, are responsible for generating visual signals when stimulated by light, while retinal ganglion cells transmit these signals to the brain. While regenerating retinal neurons and connections has shown success in fish, mice, and other systems, the ultimate objective of the AGI is to restore vision in humans.
Required information for application:
1. Applicant Information:
- Name of the applicant(s)
- Contact information (address, phone number, email)
- Affiliation/institution
2. Project Title:
- A clear and concise title for the proposed project
3. Project Summary:
- A brief summary of the project objectives, methods, and expected outcomes (limited to a specified word/character count)
4. Project Description:
- Detailed description of the proposed project, including the rationale, methodology, significance, and innovation
- Explanation of how the project aligns with the NEI Audacious Goal Initiative and targets the regeneration of photoreceptors and retinal ganglion cells
- Description of any relevant preliminary data or previous research related to the project
- Expected timeline for the project
5. Budget:
- Detailed breakdown of the proposed project budget, including personnel, equipment, supplies, and other relevant expenses
6. Biographical Sketches:
- Curriculum vitae (CV) or biographical sketches of the principal investigator (PI) and key personnel involved in the project
7. Research Plan:
- Description of the specific aims and objectives of the project
- Detailed experimental design and methods
- Data analysis plan
- Potential challenges and alternative approaches
8. Project Collaboration:
- Description of any collaborations or partnerships involved in the project, including letters of support or commitment from collaborating institutions or individuals
9. Ethical Considerations:
- Statement addressing ethical considerations related to the proposed study, including human subjects research or animal use (if applicable)
- Description of any necessary ethical approvals or institutional review board (IRB) clearances
10. Dissemination and
