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Pancreatic Cancer Detection Consortium: Management and Data Coordination Unit (U24 Clinical Trial Not Allowed)

List of required information for application:

1. Project title

2. Principal investigator(s) information (name, contact information, affiliations)

3. Background and significance of the proposed research

4. Research objectives and aims

5. Proposed approach/methodology for early detection of pancreatic ductal adenocarcinoma (PDAC) and characterization of its precursor lesions

6. Description of multi-disciplinary team composition

7. Plan for identifying and testing biomarkers measurable in bodily fluids for early detection of PDAC and/or its precursor lesions

8. Plan for determining which pancreatic cysts are likely to progress to cancer

9. Proposed molecular- and/or imaging-based approaches for screening populations at high risk of PDAC

10. Approach towards biomarker discovery and/or validation using machine learning and computational methods

11. Plan for conducting biomarker validation studies

12. Description of proposed biorepository building efforts and collection of longitudinal biospecimens

13. Plan for collaboration and sharing of ideas, biospecimens, and data within the Pancreatic Cancer Detection Consortium (PCDC)

14. Plan for participation in collaborative activities with other PCDC research units

15. Proposed roles and responsibilities of the Management and Data Coordination Unit (MDCU) in study design, protocol development, statistical analysis, coordination, harmonization, data management, and stewardship for trans-PCDC collaborative projects

16. Budget and budget justification for the proposed research

17. Timeline and milestones for the proposed research

18. Expected outcomes and potential impact of the research

19. References to support the proposed research and approach

Note: This list of required information may not be exhaustive and additional requirements may be specified in the official grant application guidelines.

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