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Precision Mental Health: Develop Tools to Inform Treatment Selection in Depression (UG3/UH3 Clinical Trial Optional)

- A sensitive biomarker/tool to predict individual treatment-response in depression

- Preliminary studies (retrospective secondary analyses of data and/or nimble, fast-fail pilot studies) demonstrating the clinical utility of the test technology

- Futility analyses, ROC curves, and/or effect size evaluation as go/no-go criteria for the test technology

- Large-scale biomarker/tool-stratified clinical trials to prospectively test the efficacy of the biomarker/tool

- Beating standard-of-care decision-making in clinician/patient treatment assignment as the goal of the clinical trials

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88%

Approval rating across all Canadian funding programs

93%

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