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Quantifying the Impact of Environmental Toxicants on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) Risk in Cohort Studies (U01 Clinical Trial Not Allowed)

List of required information for application:

1. Proposed research project title

2. Project abstract

3. Detailed research plan outlining the objectives, methods, and expected outcomes

4. Background and significance of the study, highlighting the need to quantify the impact of environmental toxicants on Alzheimer's Disease (AD) and AD-related Dementias (ADRD) risk

5. Description of the major toxicants that will be investigated and their association with elevated AD risk

6. Explanation of how the research will address health disparities in AD-related pathologic and clinical outcomes

7. Description of the existing longitudinal cohorts that will be enriched with measures of exposures to toxicants or multi-omics molecular profiling

8. Justification for the selection of specific toxicants or combinations of toxicants

9. Explanation of how multi-disciplinary teams will be developed to ensure rigorous measurement and assessment of environmental exposures at the population level

10. Detailed plan for creating an environmental epidemiology consortium to facilitate rapid and broad data sharing, harmonization, and integration of complex exposure data across multiple studies

11. Description of how data pooling and data integration will enhance the opportunity for meta-analyses and/or comparative analyses

12. Budget and budget justification, including personnel, equipment, and research materials

13. Timeline for the proposed research project

14. Description of the applicant's qualifications and expertise in conducting research related to environmental toxicants and Alzheimer's Disease

15. References to relevant literature and studies supporting the proposed research project.

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