List of Required Information for Application:
1. Project Title: The application should include a title that accurately reflects the proposed research question and objectives.
2. Abstract: A brief summary of the proposed project, including the aims, significance, and expected outcomes.
3. Introduction: A detailed introduction describing the background and rationale for the proposed research question in brain aging and Alzheimer's disease (AD) and Alzheimer's Disease Related Dementias (ADRD).
4. Specific Aims: Clear and concise statements of the specific research objectives and goals that the project aims to achieve.
5. Research Plan: A detailed description of the experimental and computational approaches that will be used to address the research question. This should include information on the experimental models, computational models, and any data integration or analysis methods that will be employed.
6. Interdisciplinary Collaboration: A description of how the proposed project will establish or expand interdisciplinary collaborations between experimental and computational researchers. This should include information on the roles and contributions of each team member, as well as plans for communication and coordination.
7. Preliminary Data: Any preliminary data or pilot studies that support the feasibility and potential of the proposed research question.
8. Significance: A discussion of the potential impact and significance of the proposed research in advancing the understanding and treatment of brain aging and AD/ADRD.
9. Innovation: A description of how the proposed research represents a novel and innovative approach to addressing the research question.
10. Timeline: A detailed timeline outlining the proposed activities and milestones for the project, including the R21 support period and the R33 support period.
11. Budget: A detailed budget plan outlining the estimated costs for personnel, supplies, equipment, and any other resources required for the project.
12. Resources: A description of the institutional resources and facilities that will be available to support the proposed research.
13. References: A list of relevant references cited throughout the application.
14. Biographical Sketches: Biographical sketches or CVs for the key investigators and team members involved in the project.
15. Letters of Support: Letters of support from collaborating institutions or individuals who will be involved in the project.
16. Human Subject Protection: If applicable, information on the plans for human subject recruitment, consent, and protection, as well as any institutional review board (IRB) approvals obtained or pending.
17. Animal Welfare: If applicable, information on the plans for animal research, including the species, the number of animals involved, and any institutional animal care and
